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| Product Name | TACE, CT, Rat Control Peptide (TNF-alpha Converting Enzyme) |
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| Description | Highly purified. TACE (rat/mouse 827 aa, human 824 aa) is transmembrane protease of ADAM family. A 17 aa peptide near the C-terminus of rat TACE (1). beta-amyloid (Ab) deposition in the brain is the hallmark of Alzheimer's Disease (AD). To initiate Ab formation, beta-secretase cleaves APP at the N-terminus of Ab to release APPsb (~100kD soluble NT-fragment), and C99, a 12-kD CT membrane fragment. Alternatively, alpha-secretase cleaves within the Ab to prevent the formation of Ab. Cleavage by a-secretase produces a soluble N-terminal fragment, APPsa, and a 10-kD membrane C-terminal fragment, C83. Both C99 and C83 can be further cleaved by gamma-secretase releasing Ab and a nonpathogenic p3 peptide, respectively. Recently TACE, a member of the ADAM family (A Disintegrin And Metalloprotease family) protease has been shown to play a central role in a regulated cleavage of human APP. Inhibition of TACE affects both APP secretion and Ab formation in cultured cells (1). Membrane-bound TNF-a, |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | T0500-10A |
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| Order / More Info | TACE, CT, Rat Control Peptide (TNF-alpha Converting Enzyme) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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