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| Product Name | TACI, Recombinant, Human (Transmembrane Activator and CAML Interactor, TNFRSF13B) |
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| Description | Purity ~98% (SDS-PAGE). TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 159aa polypeptide comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein. Source: Recombinant protein corresponding to human TACI expressed in E. coli. Molecular Weight: ~17.8kD Biological Activity: Determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1-3ug/ml. Endoto |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ransmembrane activator and CAML interactor, TNFRSF13B |
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| Gene, Accession, CAS # | TACI, Gene ID: 23495, Accession: O14836 |
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| Catalog # | 220301 |
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| Order / More Info | TACI, Recombinant, Human (Transmembrane Activator and CAML Interactor, TNFRSF13B) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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