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| Product Name | Formiminotransferase Cyclodeaminase, Recombinant, Human |
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| Description | Purity ≥ 95% (SDS-PAGE). Formiminotransferase cyclodeaminase, a bifunctional enzyme of tetrahydrofolate synthesis, is the target antigen of anti-LC1 (liver cytosol antigen type 1) autoantibodies. Presence of LC1 autoantibodies is a marker for type 2 autoimmune hepatitis (for which anti-LKM 1/cytochrome P450 2D6 autoantibodies are a further marker). Serum LC1 autoantibody concentrations appear to fluctuate in parallel with aminotransferase levels, a particularly intriguing observation that suggests a possible role of LC1 autoreactivity in the pathogenic mechanism leading to hepatocyte injury. Description: Recombinant Human Formiminotransferase Cyclodeaminase 1 produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 59,749 dalton. Recombinant LC-1 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. Immunological functions: 1. Binds IgG-type human auto-antibodies. 2. Standard ELISA test (checker-board analysis of positive/negative |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | F6002-20 |
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| Order / More Info | Formiminotransferase Cyclodeaminase, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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