| 产品详情 |
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| Product Name | ICMT Inhibitor II, FTPAT |
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| Description | Purity ~98% (HPLC). A cell-permeable triazolo-farnesylthiopropanoate compound that acts as a potent, reversible, and isoprenyl mimetic competitive inhibitor of isoprenylcysteine carboxyl methyltransferase activity (ICMT; IC50=800nM; Ki=400nM). Shown to prevent K-Ras membrane localization in GFP-K-Ras transfected Jurkat T-cells. Exhibits selective toxicity towards wt-Icmt+/+ mouse embryonic fibroblasts (MEFs) over Icmt-/- MEFs (IC50=33 and >100uM). Also shown to arrest the proliferation of PaTu-8902, a highly metastatic pancreatic cancer cells (IC50=8uM). Formula: C26H31N3O2S Molecular Weight: 449.6 Solubility: DMSO (50mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ICMT Inhibitor II, FTPAT ((E)-methyl-3-((5-(4-(2-((1,1'-biphenyl]-4-yl)ethyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217448 |
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| Order / More Info | ICMT Inhibitor II, FTPAT from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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