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| Product Name | Bacillus anthracis PA (Protective Antigen), Recombinant (Anthrax) |
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| Description | Single major band by SDS-PAGE, MW: 63kD. B. anthracis PA83 is the proteolytically activated in vivo by a furin-like protease to produce a 63kD protein PA63. It is one of the three protein components of anthrax toxin, protective antigen (PA) is the central moiety that mediates the entry of lethal factor and edema factor into the target cell. PA binds to the cell surface via a type I membrane protein with a von Willebrand factor A domain called anthrax toxin receptor. After inhalation by mammals, Bacillus anthracis spores germinate in alveolar macrophages then migrate to lymph nodes where they multiply. The vegetative bacteria excrete the tripartite exotoxin which consists of three polypeptides: protective antigen (PA, 83kD), lethal factor (LF, 90kD) and oedma factor (OF, 89kD). The two components (OF and LF) of the toxin enzymatically modify substrates within the cytosol of the mammalian cells: The OF is an adenylate cyclase that impairs the host defenses through a variety of mechanisms |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | B0003-05T5 |
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| Order / More Info | Bacillus anthracis PA (Protective Antigen), Recombinant (Anthrax) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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