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| Product Name | A-1155463 Hydrochloride |
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| Description | A-1155463 Hydrochloride, is a potent and selective BCL-XL inhibitor with in vivo activity. A-1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of <0.01nM (7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). A-1155463, together with A-1331852 , represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, A-1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2-BIM, complexes, killing BCL-XL-dependent Molt-4 cells (EC50=70nM) without measurable cytotoxicity against BCL-2-dependent RS4 (ref. 1), inducing the hallmarks of intrinsic apoptosis (ref. 1). Molecular Formula: C35H32FN5O |
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| Size | 1mg, 2.5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 440627 |
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| Order / More Info | A-1155463 Hydrochloride from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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