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| Product Name | Interleukin-36 alpha, active (Il36a), Recombinant, Mouse |
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| Description | Purity ≥95% as determined by SDS-PAGE and HPLC. Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T cells and splenocytes. May play a role in proinflammatory effects in the lung |
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| Size | 2ug, 10ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | FIL1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6, Interleukin-1 homolog 1 |
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| Gene, Accession, CAS # | IL36A_MOUSE, SwissProt: Q9JLA2 |
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| Catalog # | 348131 |
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| Order / More Info | Interleukin-36 alpha, active (Il36a), Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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