| 产品名称 |
IDO, Recombinant, Human, Active, aa1-403, His-Tag (Indoleamine 2,3-dioxygenase, INDO) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | IDO, Recombinant, Human, Active, aa1-403, His-Tag (Indoleamine 2,3-dioxygenase, INDO) |
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| Description | Purity ≥90% (SDS-PAGE). IDO is a heme enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO is an immune checkpoint protein, thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity. Cancer cells are able to evade the immune system is by hijacking the checkpoint proteins. Increased IDO protein levels drive growth arrest and apoptosis of the effector T cells, a group of immune cells that mediate the immune system's ability to destroy pathogens. By reducing the number of effector T cells, IDO overexpression prevents the immune system from effectively destroying cancer cells. IDO overexpression has been observed in a wide range of human cancers such as prostatic, colorectal, pancreatic, cervical, gastric, ovarian, head or lung |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P14902 |
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| Catalog # | 348277 |
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| Price | |
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| Order / More Info | IDO, Recombinant, Human, Active, aa1-403, His-Tag (Indoleamine 2,3-dioxygenase, INDO) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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