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| Product Name | IDO, Recombinant, Mouse (His) (Indoleamine 2,3-dioxygenase, INDO) |
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| Description | Purity >90% (SDS-PAGE) Endotoxin: ≤1EU/ug (LAL). IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders. Recombinant protein corresponding to mouse IDO (aa1-407), at C-terminus fused to His-tag. Biological Activity: Specific Activity: >100,000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour. Heme Content: Not determined for end product. 7uM hemin was adde for protein induction. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Indoleamine 2,3-dioxygenase, INDO |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 44896 |
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| Order / More Info | IDO, Recombinant, Mouse (His) (Indoleamine 2,3-dioxygenase, INDO) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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