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| Product Name | 9-Phenanthrol, TRPM4 Inhibitor (Phenanthren-9-ol, 9-Hydroxyphenanthrene) |
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| Description | Purity ~95% (HPLC). A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50=20uM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolishnMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10uM, but at higher concentration (~100uM) it reversibly reduces K+ currents. Formula: C14H10O Molecular Weight: 194.2 Solubility: DMSO (50mg/ml) |
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| Size | 50mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217133 |
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| Order / More Info | 9-Phenanthrol, TRPM4 Inhibitor (Phenanthren-9-ol, 9-Hydroxyphenanthrene) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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