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LRRK2, Recombinant, Human, GST-Tag (Leucine-rich Repeat Kinase 2, PARK8, RIPK7, ROCO2, AURA17, DARDARIN) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | LRRK2, Recombinant, Human, GST-Tag (Leucine-rich Repeat Kinase 2, PARK8, RIPK7, ROCO2, AURA17, DARDARIN) |
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| Description | Purified (~70-90%). LRRK2 or leucine-rich repeat kinase is a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. Mutations in LRRK2 are the most frequent known cause of autosomal dominant and idiopathic Parkinson's disease with prevalent mutations being found within the GTPase and kinase domains. LRRK2 cooperates with MET to promote efficient tumor cell growth and survival in various cancers. Down-regulation of LRRK2 in cultured tumor cells compromises MET activation and selectively reduces downstream MET signaling to mTOR and STAT3. Source: Recombinant protein corresponding to human LRRK2, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~210kD Specific Activity: 6nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_198578 |
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| Catalog # | 500216 |
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| Price | |
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| Order / More Info | LRRK2, Recombinant, Human, GST-Tag (Leucine-rich Repeat Kinase 2, PARK8, RIPK7, ROCO2, AURA17, DARDARIN) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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