| 产品详情 |
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| Product Name | LSD1 Inhibitor III, CBB1007 |
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| Description | Purity ~99% (HPLC). A cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50=5.27uM for hLSD1) and efficiently blocks LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50≤5uM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50≤5uM), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50≤3.74uM). Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50≥100uM). Formula: C27H34N8O4 • 3CF3CO2H Solubility: DMSO Molecular Weight: 534.6 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LSD1 Inhibitor III, CBB1007 (Histone Lysine Demethylase Inhibitor V, CBB1007, KDM1 Inhibitor III, CBB1007) (Methyl-3-(4-(4-carbamimidoylbenzoyl)piperazine-1-carbonyl)-5-((4-carbamimidoylpiperazin-1-yl)methyl)benzoate, BHC110 Inhibitor III, Lysine Specific Demethylase Inhibitor VI) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217520 |
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| Order / More Info | LSD1 Inhibitor III, CBB1007 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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