| 产品详情 |
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| Product Name | LSD1 Inhibitor IV, RN-1,HCl |
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| Description | Purity ~97% (HPLC). A cell-permeable tranylcypromine (parnate) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50=70nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50=0.51 and 2.785uM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10mg/kg, i.p.). Formula: C23H29N3O2. HCl Solubility: DMSO or H2O Molecular Weight: 416 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LSD1 Inhibitor IV, RN-1,HCl (2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, Lysine (K)-Specific Demethylase Inhibitor IV,RN-1,HCl, BHC110 Inhibitor IV, KDM1 Inhibitor IV, MOA Inhibitor III) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217521 |
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| Order / More Info | LSD1 Inhibitor IV, RN-1,HCl from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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