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| Product Name | ARHGDIA, Recombinant, Human, aa2-204, GST-Tag (Rho GDP-dissociation Inhibitor 1) |
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| Description | Purity ~90% (SDS-PAGE). Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from th, and the subsequent binding of GTP to th. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SA5A and PLXNB3 that lead to inactivation of RAC1. Source: Recombinant protein corresponding to aa2-204 from human ARHGDIA, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~50.1kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Rho-GDI alpha |
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| Gene, Accession, CAS # | SwissProt: P52565 |
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| Catalog # | 372327 |
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| Order / More Info | ARHGDIA, Recombinant, Human, aa2-204, GST-Tag (Rho GDP-dissociation Inhibitor 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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