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| Product Name | L- Buthionine Sulfoximine |
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| Description | Purity ~97% (TLC). A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29uM in melanoma, breast, and ovarian tumor cells, respectively). Solubility: H2O Primary Target: gamma-glutamylcysteine synthetase |
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| Size | 100mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217497 |
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| Order / More Info | L- Buthionine Sulfoximine from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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