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| Product Name | CDKN1A, Recombinant, Human, aa2-164, GST-Tag (Cyclin-dependent Kinase Inhibitor 1) |
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| Description | Purity ~90% (SDS-PAGE). May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Source: Recombinant protein corresponding to aa2-164 from human CDKN1A, fused to GST-Tag at N-terminal expressed in E. coli. Molecular Weight: ~45kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CDK-interacting protein 1Melanoma differentiation-associated protein 6, MDA-6p21 |
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| Gene, Accession, CAS # | SwissProt: P38936 |
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| Catalog # | 372703 |
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| Order / More Info | CDKN1A, Recombinant, Human, aa2-164, GST-Tag (Cyclin-dependent Kinase Inhibitor 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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