| 产品详情 |
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| Product Name | MT1-MMP Inhibitor, NSC405020 |
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| Description | Purity ~98% (HPLC). A cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-b3/MT tumor growth in xenografted mice (0.5mg/kg, intratumoral). Formula: C12H15Cl2NO Solubility: DMSO Molecular Weight: 260.2 |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MT1-MMP Inhibitor, NSC405020 (3,4-Dichloro-N-(1-methylbutyl)benzamide, 3,4-Dichloro-N-(pentan-2-yl)benzamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217568 |
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| Order / More Info | MT1-MMP Inhibitor, NSC405020 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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