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| Product Name | Envelope Glycoprotein, Recombinant, Sudan Ebolavirus, aa502-637, His-Tag (GP) |
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| Description | Purity ~90% (SDS-PAGE). GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection). Binding to the macrophage specific lectin CLEC10A also seems to enhance virus infectivity. Interaction with FOLR1/folate receptor alpha may be a cofactor for virus entry in some cell types, although results are contradictory. After internalization of the virus into the endosomes of the host cell, proteolysis of GP1 by two cysteine proteases, CTSB/cathepsin B and CTSL/cathepsin L presumably induces a conformational |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GP1,2, GP |
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| Gene, Accession, CAS # | SwissProt: Q7T9D9 |
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| Catalog # | 373200 |
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| Order / More Info | Envelope Glycoprotein, Recombinant, Sudan Ebolavirus, aa502-637, His-Tag (GP) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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