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| Product Name | HPV E6, Recombinant, Viral (HpV16gp1, HPV Early Protein 6, Papillomavirus E6) |
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| Description | Purity ~98% (SDS-PAGE) under reducing conditions and visualized by Colloidal Coomassie Blue Stain. E6 (Early protein 6) is a viral protein produced in cells infected with the Human Papillomavirus. E6 forms a complex with the host cell ubiquitin ligase E6AP (E6-Associated-Protein) generating a ligase activity that polyubiquitinates tumor suppressors p53 and p73 and targets them to the 26S proteasome for degradation. As a result DNA damage and chromosomal instabilities increase, often leading to cell proliferation and cancer. The E6/E6AP complex also targets other substrates for ubiquitination, such as TERT, BAK1, FADD, and pro-CASP8 - none of which appear to be substrates for E6AP in the absence of E6. This protein is untagged, and contains six cysteine-to-serine substitutions at positions 23, 58, 87, 104, 118, and 147 (HPV type 16 sequence numbering). Source: Recombinant protein corresponding to HPV E6, expressed in E. coli. Contains Cys to Ser substitutions at the following positions: 2 |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 1489078, SwissProt: Q547J2 |
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| Catalog # | 145802 |
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| Order / More Info | HPV E6, Recombinant, Viral (HpV16gp1, HPV Early Protein 6, Papillomavirus E6) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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