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| Product Name | mTOR Activator, MHY1485 |
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| Description | Purity ~97% (HPLC). A cell-permeable triazine derivative that is shown to increase cellular mTOR Ser2448 and downstream substrate 4E-BP Thr37/46 phosphorylation level in rat liver Ac2F cells (1 to 2uM for 1h), affecting culture viability only at much higher concentrations (by 20% after 24h 20uM treatment). MHY1485 induced cellular LC3-II accumulation in Ac2F is reported to be a result of autophagy inhibition due to reduced fusion between autophagosomes and lysosomes. The mechanism of mTOR activation by MHY1485 is currently unknown. Primary Target IC50: ~2u Solubility: DMSO Molar Mass: 387.39 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | mTOR Activator, MHY1485 (4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine, Autophagy Inhibitor III) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217570 |
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| Order / More Info | mTOR Activator, MHY1485 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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