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| Product Name | Epidermal Growth Factor Receptor, Fc Chimera, Human |
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| Description | Purity ~95% (SDS-PAGE). Epidermal Growth Factor (EGF) Receptor binds to EGF and other members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. 4 isoforms are produced by alternative splicing (reference SWISSPROT). The EGF receptor is a single-pass type I membrane protein containing an extracellular receptor domain, a transmembrane region and an intracellular domain with tyrosine kinase function. Source: Epidermal Growth Factor Receptor-Fc Chimera, from human DNA sequence encoding the signal peptide and extracellular domain of human Epidermal Growth Factor Receptor aa1-525 was fused to the Fc region of human IgG1 aa90-330. The chimeric protein was expressed in modified human 293 cells. Molecular Weight: ~85kD-110kD with post-translation modification and ~83kD unmodified. Biological Activity: The ED50 of the EGF receptor-Fc chimera is typically 60-100ng/ml as measured by its ability to neutrali |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Epidermal Growth Factor Receptor, Fc Chimera, Human (Receptor Tyrosine-protein Kinase ErbB-1, EGFR, Urogastrone, Pro-epidermal Growth Factor, EGF R, C-erbB-1, ERBB1) |
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| Gene, Accession, CAS # | SwissProt: P00533 |
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| Catalog # | 215283 |
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| Order / More Info | Epidermal Growth Factor Receptor, Fc Chimera, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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