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| Product Name | Epidermal Growth Factor Receptor, L858R, Recombinant, Human, GST-Tag (erbB, EGFR) |
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| Description | Purity ≥70%. The L858R mutation has been associated with non-small cell lung cancer patients who demonstrate clinical responsiveness to the tyrosine kinase inhibitor gefitinib (Iressa, ZD1839). Source: Recombinant human EGFR L858R, aa668-1210, with N-terminal GST tag, expressed in baculovirus expression system. Molecular Weight: 88kD Specific Activity: 317pmol/min/ug Reaction Buffer: 50mM HEPES (pH7.5), 10mM MgCl2, 1mM EDTA, 0.01% BRIJ- 35 and 200uM of ATP. Substrate: 2uM Tyr peptide 4 from Invitrogen. Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_005228 |
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| Catalog # | E3375-48A |
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| Order / More Info | Epidermal Growth Factor Receptor, L858R, Recombinant, Human, GST-Tag (erbB, EGFR) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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