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| Product Name | Carboxy terminus of HSP70 interacting protein, 1-303 aa, Recombinant Human |
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| Description | Purity ≥ 90% (SDS-PAGE). CHIP, also known as STUB1, is a cytoplasmic protein whose amino acid sequence is highly conserved across species. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, whereas its U-box domain contains its E3 ubiquitin ligase activity. Its interaction with these molecular chaperones results in client substrate ubiquitylation and degradation by the proteasome. Thus, CHIP acts to tilt the folding-refolding machinery toward the degradative pathway, and it serves as a link between the two. Recombinant human CHIP protein was expressed in E. coli and purified by using conventional chromatography techniques. Accession: NP_005852 AA sequence: MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI TYDRKDIEEH LQRVGHFDP |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Carboxy terminus of HSP70 interacting protein, 1-303 aa, Recombinant Human (CHIP, STUB1, HSPABP2, NY-CO-7, SDCCAG7, UBOX1) |
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| Gene, Accession, CAS # | Accession: NP_005852 |
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| Catalog # | C4125-03D |
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| Order / More Info | Carboxy terminus of HSP70 interacting protein, 1-303 aa, Recombinant Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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