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| Product Name | Osteonectin, Recombinant, Human (SPARC, Secreted Protein Acidic and Rich in Cysteine, BM-40, ON) |
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| Description | Purity ~97% (SDS-PAGE). SPARC/Osteonectin is a secreted, evolutionarily conserved collagen-binding glycoprotein that is involved in a variety of cellular activities. It is highly expressed in tissues undergoing morphogenesis, remodeling and wound repair. SPARC/Osteonectin and its related peptides bind to numerous proteins of the extracellular matrix (ECM), affect ECM protein expression, influence cellular adhesion and migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC/Osteonectin consists of three domains; an N-terminal acidic region that binds calcium ions with low affinity, a module containing two EF-hand motifs that bind calcium with high affinity, and a cysteine-rich follistatin-like domain. Source: Recombinant protein corresponding to 286aa from human Osteonectin, expressed in CHO cells. Molecular Weight: ~43.7kD, by SDS-PAGE analysis due to the effect of glycosylation Biological Activity: Determined by its ability to increase alkaline phospha |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ecreted protein acidic and rich in cysteine, BM-40, ON |
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| Gene, Accession, CAS # | SPARC, Gene ID: 6678, SwissProt: P09486 |
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| Catalog # | 220118 |
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| Order / More Info | Osteonectin, Recombinant, Human (SPARC, Secreted Protein Acidic and Rich in Cysteine, BM-40, ON) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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