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| Product Name | OPTN, Recombinant, Human, aa1-577, His-Tag (Optineurin) |
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| Description | Purity ~90% (SDS-PAGE). Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | E3-14.7K-interacting protein, FIP-2 Huntingtin yeast partner L Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L NEMO-related protein, Optic neuropathy-inducing protein Transcription factor IIIA-interacting protein,TFIIIA-IntP |
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| Gene, Accession, CAS # | SwissProt: Q96CV9 |
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| Catalog # | 374550 |
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| Order / More Info | OPTN, Recombinant, Human, aa1-577, His-Tag (Optineurin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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