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| Product Name | Tissue Factor [Cys39] (33-53) |
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| Description | Purity ~95%. Purified by HPLC. Sequence (linear): Val-Tyr-Thr-Val-Gln-Ile-Cys-Thr-Lys-Ser-Gly-Asp-Trp-Lys-Ser-Lys-Cys-Phe-Tyr-Thr-Thr Tissue Factor (TF) is expressed in the plasma membranes of many cell types. It is an integral membrane glycoprotein consisting of a single chain molecule of 44kD. TF consists of an extracellular domain (residues 1-219), a transmembrane domain (residues 220-242) and the C-terminal intracellular domain (residues 243-263). Most abundant in the tissue adventitia, TF becomes exposed to blood at the site of vascular injury. The availability of TF is important in initiating coagulation by acting as a receptor for both the zymogen and protease forms of plasma Factor VII (FVII and FVIIa). It also mediates the conversion of bound FVII to FVIIa. The binding of FVII to TF in the presence of a negatively charged surface such as a phospholipid (or cell surface) promotes the auto activation of FVII by FVIIa. The TF-FVIIa complex in the presence of calcium ions proteoly |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Val-Tyr-Thr-Val-Gln-Ile-Cys-Thr-Lys-Ser-Gly-Asp-Trp-Lys-Ser-Lys-Cys-Phe-Tyr-Thr-Thr |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | T5575-01B |
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| Order / More Info | Tissue Factor [Cys39] (33-53) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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