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SOS1, Recombiant, Human, aa564-1049, His-Tag (Son of Sevenless Homolog 1, SOS1, GF1, GGF1, GINGF, HGF, NS4) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | SOS1, Recombiant, Human, aa564-1049, His-Tag (Son of Sevenless Homolog 1, SOS1, GF1, GGF1, GINGF, HGF, NS4) |
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| Description | Purity ~95% (SDS-PAGE). SOS1, also known as son of sevenless homolog 1, is a Ras and Rac guanine nucleotide exchange factor. This protein is composed of several important domains. The CDC25 and REM domains provide the catalytic activity of SOS1 towards Ras and the histone fold DH/PH (Dbl homology and Pleckstrin homology) domains function, in tandem, to stimulate GTP/GDP exchange for Rac. Also, binding of GTP activates Ras proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). Source: Recombinant protein corresponding to aa564-1049 from human SOS1, fused to His-Tag at C-terminal, expressed in Insect Cell. Molecular Weight: ~58kD (495aa) ~50-70kD (SDS-PAGE under reducing conditions.) AA |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_005624 |
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| Catalog # | 470256 |
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| Price | |
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| Order / More Info | SOS1, Recombiant, Human, aa564-1049, His-Tag (Son of Sevenless Homolog 1, SOS1, GF1, GGF1, GINGF, HGF, NS4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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