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| Product Name | SOST, BioAssay™ ELISA Kit (Sclerostin, UNQ2976/PRO7455/PRO7476) |
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| Description | SOST, also known as Sclerostin, is a Cerberus/DAN family member and is an important regulator of bone homesotasis. Cerberus/DAN proteins (Cerberus, DAN, Gremlin, PRDC, and Caronte) are secreted glycoproteins that function as BMP antagonists. While the overall sequence identity between members of the family is low, they share a cysteine-knot motif with conserved spacing of six cysteine residues. SOST is secreted as a monomer in contrast to many other cysteine-knot proteins which form disulfide-linked homodimers. Mature mouse SOST shares 89% and 95% aa sequence identity with human and rat SOST, respectively. Inactivating mutations in the SOST gene can cause sclerosteosis and van Buchem disease which are bone dysplasia disorders characterized by progressive skeletal overgrowth. SOST is expressed by terminally differentiated cells embedded in mineralized matrix including osteocytes, hypertrophic and prehypertrophic chondrocytes, and tooth cementocytes. SOST expression is induced by BMP-2, |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | S0501-06 |
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| Order / More Info | SOST, BioAssay™ ELISA Kit (Sclerostin, UNQ2976/PRO7455/PRO7476) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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