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| Product Name | GSK-3 Inhibitor IX ((2'Z,3'E)-6-Bromoindirubin-3'-oxime) |
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| Description | Purity ~97% (HPLC). A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3a/b (IC50=5nM). Its specificity has been tested against various Cdk's (IC50=83, 300, 320, and 10,000nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50≥10uM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10mM (500ug/140ul) solution of GSK-3 Inhibitor IX in DMSO is also available. Formula: C16H10BrN3O2 Primary Target: GSK-3a/b Primary Target IC50: 5nM Secondary Target: IC50 = 83, 300, 320, and 10,000nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respecti |
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| Size | 1mg, 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217401 |
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| Order / More Info | GSK-3 Inhibitor IX ((2'Z,3'E)-6-Bromoindirubin-3'-oxime) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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