| 产品详情 |
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| Product Name | LSF Inhibitor, FQI1 |
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| Description | Purity ~92% (HPLC). A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50=2.1uM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50=3.8, 0.79, and 6.3uM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1mg/kg, i.p., once every 3 days). Formula: C18H17NO4 Molecular Weight: 311.3 Solubility: DMSO (100mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LSF Inhibitor, FQI1 ((±, 8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one Factor Quinolinone Inhibitor 1, Racemic) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217522 |
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| Order / More Info | LSF Inhibitor, FQI1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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