| 产品详情 |
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| Antigenic Specificity | YAP / YAP1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | immunoaffinity purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA (1:5000 - 1:20000), WB (1:1000 - 1:10000) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | YAP / YAP1 Antibody LS-C415675. Specificity: YAP (Yes-associated protein) is a transcription coactivator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis and in organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteosomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. Dysregulation of the Hippo-YAP pathway is frequently observed in human cancers. AMPK directly phosphorylates YAP at Ser94, a residue essential for the interaction with TEAD, thus disrupting the YAP-TEAD interaction. |
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| Immunogen | KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser94 of human YAP1. |
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| Other Names | YAP1, 65 kDa Yes-associated protein, YAP, Yes-associated protein beta, Yes-associated protein delta, Yorkie homolog, YAP2, Yes-associated protein 1, Yes-associated protein 2, YKI, YAP65 |
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| Gene, Accession # | YAP1, Gene ID: 10413 |
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| Catalog # | LS-C415675 |
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| Price | |
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| Order / More Info | YAP / YAP1 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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