| 产品详情 |
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| Product Name | PIM-Kinase Inhibitor IX, SGI-1776 |
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| Description | Purity ~99% (HPLC). A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50=7, 363, 69, 44 and 34nM, respectively) with moderate (40% inhibition at 1uM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62 and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50 <10uM). Formula: C20H22F3N5O · 2H2SO4 Molecular Weight: 601.6 Solubility: DMSO (100mg/ml, clear, nearly colorless solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PIM-Kinase Inhibitor IX, SGI-1776 (N-((1-Methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, 2H2SO4) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217663 |
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| Order / More Info | PIM-Kinase Inhibitor IX, SGI-1776 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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