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| Product Name | PIM Kinase Inhibitor VIII, R8-T198wt (NH2-GGGRRRRRRRRGC~KKPGLRRRQT-CO2H, cpm-P27Kip1189-198) |
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| Description | Purity ~95% (HPLC). The human p27Kip1 C-terminus PIM-1 phosphorylation site- (Thr198) containing sequence is synthesized with an N-terminal Arg octamer/R8-containing sequence to facilitate its use as a cell-permeable, substrate-competitive PIM-1 inhibitor. Reported to completely prevents human prostate carcinoma DU145-derived tumor expansion for up to 17 days (0.5umol/animal on days 0 & 5; intratumoral injection) in mice in vivo when combined with a single Taxol dosage on day zero (60mg/kg; i.p.). Studies using FITC-conjugated R8-T198wt demonstrate that R8-T198wt-induced cell cycle arrest and apoptosis in PIM-1-expressing DU145 cells are direct consequences of inhibition of PIM-1-mediated p27Kip1 Thr198 and Bad Ser112 phosphorylation, respectively. Formula: C111H211N59O26S1 Sequence: H-Gly-Gly-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Cys-Lys-Lys-Pro-Gly-Leu-Arg-Arg-Arg-Gln-Thr-OH Molecular Weight: 2820.4 Solubility: DMSO (50mg/ml, clear, colorless solution) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217662 |
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| Order / More Info | PIM Kinase Inhibitor VIII, R8-T198wt (NH2-GGGRRRRRRRRGC~KKPGLRRRQT-CO2H, cpm-P27Kip1189-198) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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