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| Product Name | IGFBP-2, BioAssay™ ELISA Kit (Human) (Insulin Like Growth Factor Binding Protein 2) |
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| Description | The superfamily of secreted insulin-like growth factor (IGF) binding proteins includes high-affinity IGF binding proteins (IGFBP) and low-affinity binding proteins referred to as IGFBP-like or IGFBP- related proteins (IGFBPL, IGFBP-rP) (1). IGFBPs form complexes with IGF-I and -II, modulating their activity and bioavailability by modifying their binding to cell receptors, cell surfaces, and the extracellular matrix (1-5). In addition to direct effects on activity and binding of IGFs, IGFBPs act as carriers for circulating IGFs, prolonging their half-lives, and creating IGF reservoirs in tissues (1, 3, 4). IGFBP-2 and other superfamily members contain N-terminal IGF-binding domains with 12 conserved cysteines, and C-terminal thyroglobulin type 1 domains with 6 conserved cysteines (1). The C-terminal domain mediates heparin binding, which is enhanced in the presence of IGFs and, in the case of IGFBP-2, contains an RGD sequence that promotes integrin-mediated cell attachment (1, 3, 5-9). |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145744 |
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| Order / More Info | IGFBP-2, BioAssay™ ELISA Kit (Human) (Insulin Like Growth Factor Binding Protein 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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