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| Product Name | HPD, aa1- 393, Recombinant, Human |
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| Description | Purity ~90% (SDS-PAGE). 4-hydroxyphenylpyruvate dioxygenase isoform 1, also known as HPD, is an Fe-containing enzyme, that catalyzes the second reaction in the catabolism of tyrosine the conversion of 4-hydroxyphenylpyruvate to homogentisate. Existing as a homodimer, HPD uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. Defects in the gene encoding HPD are the cause of tyrosinemia type 3 and hawkinsinuria, both of which are inborn errors of metabolism that are associated with a variety of symptoms, including mental retardation and seizures and hair and urine abnormalities. Source: Recombinant corresponding to aa1-393 of human HPD protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MTTYSDKGAK PERGRFLHFH SVTFWVGNAK QAASFYCSKM GFEPLAYRGL ETGSREVVSH VIKQGKIVFV LSSALNPWNK EMGDHLVKHG DGVKDIAFEV EDCDYIVQKA RERGAKIMRE PWVEQDKFGK VKFAVLQTYG DTTHTLVEKM NYIGQFLPGY EAPAFMDPLL PKLPKC |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HPD, aa1- 393, Recombinant, Human (4-hydroxyphenylpyruvate Dioxygenase, 4-hydroxyphenylpyruvic Acid Oxidase, 4HPPD, HPPDase, PPD) |
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| Gene, Accession, CAS # | Accession: NP_002141 |
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| Catalog # | H7033-02 |
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| Order / More Info | HPD, aa1- 393, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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