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| Product Name | COX 2, Human, Western Blot Positive Control |
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| Description | Protein control for C7904-83 (affinity purified) or C7904-80H (serum). Prostaglandins are important regulators of immune responses, fever, and pain. Two isoforms of Prostaglandin H synthase are well characterized, namely COX1 (also called PGHS-1; PHS-1; Prostaglandin-endoperoxide synthase-1) and COX2 (also called PGHS-2; Prostaglandin -endoproxide synthase-2 and PHSII). Both forms of COX proteins are membrane associated heme proteins containing Cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Non steroidal anti-inflammatory drugs) such as aspirin. Cox-1 (human 599aa; rat 602aa) is homodimer of 70kD subunits. COX1 is constitutively expressed although significant enhancement of COX1 expression can be induced in some cell types. High expression is observed in gastrointestinal tissues. COX2 is a 72kD protein having 60% homology to COX1. It is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. So |
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| Size | 100ul |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | COX 2, Human, Western Blot Positive Control (PHS 2, Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C7904-81C |
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| Order / More Info | COX 2, Human, Western Blot Positive Control from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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