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| Product Name | Apolipoprotein E, Human, Western Blot Control (Apo E) |
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| Description | Apolipoprotein E (apo E), a component of lipoproteins produced by the liver and in circulating macrophages, plays a critical role in the reverse transport of cholesterol to the liver via the circulation. ApoE is also expressed in the brain and in response to injury in both the peripheral and central nervous systems. ApoE is a single polypeptide chain of 299 amino acids (~34kD) consisting of two independently folded functional domains. The C-terminal domain contains the major lipid-binding region. The N-terminal domain exists in the lipid-free state as a four-helix bundle of amphipathic a-helices and contains the LDLR-binding region (amino acids 136-150 in helix), which coincides with a heparin-binding site. Humans and mice lacking apoE cannot clear remnant lipoproteins from the plasma and are at increased risk for atherosclerosis. ApoE is a high-affinity ligand for the low density lipoprotein receptor (LDLR) family and for cell-surface heparan sulfate proteoglycans. Defective binding o |
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| Size | 100ul |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A2299-73L |
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| Order / More Info | Apolipoprotein E, Human, Western Blot Control (Apo E) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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