| 产品详情 |
| Edit |   |
|---|
| Product Name | Topoisomerase I, DNA, Recombinant, Human (Scl-70) |
|---|
| Description | Purity ≥95% (SDS-PAGE). DNA toposisomerase I is a key nuclear enzyme that interconverts supercoiled DNA to the required topological conformations for normal DNA replication and transcription. This enzyme is the target antigen for the so-called Scl-70 autoantibodies. Scl-70 antibodies are a specific marker in Scleroderma patients (specificity 98-100%) and are associated with the presence of diffuse skin involvement and pulmonary fibrosis. In human tissues the DNA topoisomerase I is initially synthesized as a protein with 100 kD molecular weight. Most of this precursor is then proteolytically processed to a species with 70 kD molecular weight from which the Scl-70 antigen has derived its name. Recombinant Human Scl-70 produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 91,576 dalton. Recombinant Scl-70 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. |
|---|
| Size | 5ug, 20ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | T8065-02 |
|---|
| Price | |
|---|
| Order / More Info | Topoisomerase I, DNA, Recombinant, Human (Scl-70) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|