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| Product Name | Topoisomerase II Inhibitor (BNS-22) |
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| Description | Purity ~99% (HPLC). A potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50=2.8uM and 0.42uM for TOP2a and TOP2b, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of y-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10uM. It also exhibits significant anti-proliferative activities against several human cancer cell lines. Formula: C24H25NO5 Solubility: DMSO Molecular Weight: 407.46 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217844 |
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| Order / More Info | Topoisomerase II Inhibitor (BNS-22) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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