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| Product Name | Topoisomerase I, Recombinant, Human, His-Tag |
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| Description | Purity ~80% (SDS-PAGE). DNA toposisomerase I is a key nuclear enzyme that interconverts supercoiled DNA to the required topological conformations for normal DNA replication and transcription. This enzyme is the target antigen for the so-called Scl-70 autoantibodies. Scl-70 antibodies are a specific marker in Scleroderma patients (specificity 98-100%) and are associated with the presence of diffuse skin involvement and pulmonary fibrosis. In human tissues the DNA topoisomerase I is initially synthesized as a protein with 100kD molecular weight. Most of this precursor is then proteolytically processed to a species with 70kD molecular weight from which the Scl-70 antigen has derived its name. Source: Recombinant protein corresponding to human TOP1, fused with a 6xHis-tag, expressed in Sf9 insect cells. Molecular Weight: ~91.57kD Specificity: Binds IgG-type human auto-antibodies. Applications: Suitable for use in ELISA, Western Blot, Biotinylation and Iodination. |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | Topoisomerase I, Recombinant, Human, His-Tag (DNA Topoisomerase-I, TOP1, TOP-I, Topoisomerase (DNA) I, Topoisomerase 1, Topoisomerase1, Topoisomerase-1, Topoisomerase-I, Type I DNA Topoisomerase) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209247 |
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| Order / More Info | Topoisomerase I, Recombinant, Human, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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