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| Product Name | Activating Transcription Factor 2, Recombinant, Human, GST-Tag (ATF2, CREB P1) |
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| Description | Purity ~70% (SDS-PAGE). ATF2 (Activating Transcription Factor 2, CREBP, HB16, CREB2, TREB7) is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, |
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| Size | 1ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_001880 |
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| Catalog # | A0855-42H1 |
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| Order / More Info | Activating Transcription Factor 2, Recombinant, Human, GST-Tag (ATF2, CREB P1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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