| 产品详情 |
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| Product Name | PNU-120596 |
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| Description | Purity ~99% (HPLC). A urea derivative that acts as a potent, selective, and reversible positive allosteric modulator for the a7 subtype of neural nicotinic acetylcholine receptors (EC50 = 216nM), with no significant effect on a4B2, a3B4 and a9a10 receptors. Specifically increase a-7 nAChR-mediated channel currents and channel mean open time in cultured neurons (~1mM). However, it does neither affect ion selectivity nor unitary conductance. Shown to cross the blood-brain barrier. Causes conformational changes in the ligand binding domain of a7 nicotinic receptors that partially overlap with those caused by acetylcholine. Causes changes in cysteine accessibility at the inner beta sheet, transition zone, and agonist binding site. Also reported to potentiate agonist-evoked GABAergic postsynaptic inward currents in somatodendritic membrane of hippocampal interneurons. Formula: C13H14ClN3O4 Molecular Weight: 311.7 Solubility: DMSO (100mg/ml, clear, colorless solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PNU-120596 (a7 nAChR Agonist, 1-(5-chloro-2,4-dimethoxy-phenyl)-3-(5-methyl-isoxazol-3-yl)-urea, α7 Neuronal Nicotinic Acetylcholine Receptor Agonist) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217680 |
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| Price | |
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| Order / More Info | PNU-120596 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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