| 产品详情 |
| Edit |   |
|---|
| Product Name | CRAC Channel Inhibitor III, Pyr6 |
|---|
| Description | Purity ~99% (HPLC). A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490nM by Fura-2), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon carbachol stimulation in TRPC3-expressing HEK293 cells (IC50 = 18.46uM; by Fura-2). A great complement to Pyr2, Pyr3, and Pyr10 in Ca2+ signaling studies. Primary Target: Orai3 Primary Target IC50: 490nM Molar Mass: 418.3 Solubility: DMSO |
|---|
| Size | 10mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | CRAC Channel Inhibitor III, Pyr6 (N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217284 |
|---|
| Price | |
|---|
| Order / More Info | CRAC Channel Inhibitor III, Pyr6 from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|