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| Product Name | RNASEL, Recombinant, Human, aa330-741, His-SUMO-Tag (2-5A-dependent Ribonuclease) |
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| Description | Purity ~90% (SDS-PAGE). Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. Source: Recombinant protein corresponding to a330-741 from human RNASEL, fused toHis-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~63.4kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Ribonuclease 4, Ribonuclease L, RNase L |
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| Gene, Accession, CAS # | SwissProt: Q05823 |
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| Catalog # | 375072 |
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| Order / More Info | RNASEL, Recombinant, Human, aa330-741, His-SUMO-Tag (2-5A-dependent Ribonuclease) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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