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| Product Name | Insulin-Like Growth Factor I Receptor, Recombinant, Mouse |
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| Description | Purity ~95% (SDS-PAGE). The insulin-like growth factor I receptor (IGF-I R or IGF1R, designated CD221) is a 450kD disulfide-linked heterotetrameric transmembrane glycoprotein consisting of two 130kD a and two 95kD b subunits (1, 4). The IGF-1 R cDNA encodes a preproreceptor that is proteolytically cleaved to produce the extracellular a subunit (aa31-737), which contains a cysteine-rich region and two ligand-binding fibronectin type III (FN-III) domains, and the b subunit (aa742-1369), which contains an extracellular FN-III domain, transmembrane and cytoplasmic tyrosine kinase domains (1). Extracellular portions of mature mouse IGF-I R share 99.7% aa identity with rat, 96% with human, canine and porcine, and 95% with bovine and equine IGF-I R. IGF-I R is expressed in all cell types and tissues. It binds insulin-like growth factor I (IGF- I) with high affinity, IGF-II with lower affinity, and insulin with lowest affinity (2, 3). Both IGF-I R and the structurally similar insulin receptor |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Insulin-Like Growth Factor I Receptor, Recombinant, Mouse (IGF-I Receptor, IGFIR, IGFR, Insulin-like Growth Factor 1 Receptor, IGF1R, CD221, JTK13, MGC18216, MGC142170, MGC142172) |
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| Gene, Accession, CAS # | SwissProt: Q60751 |
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| Catalog # | I7661-19Y |
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| Order / More Info | Insulin-Like Growth Factor I Receptor, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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