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| Product Name | RNF11, Recombinant, Human, aa2-154, His-Tag (RING Finger Protein 11) |
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| Description | Purity ~90% (SDS-PAGE). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. Source: Recombinant protein corresponding to aa2-154 from human RNF11, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~19.3kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q9Y3C5 |
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| Catalog # | 375073 |
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| Order / More Info | RNF11, Recombinant, Human, aa2-154, His-Tag (RING Finger Protein 11) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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