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| Product Name | TNF Receptor, Extracellular Domain p55, Recombinant, Human |
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| Description | Purified. ≥ 80% pure. Three bands are observed by SDS gel electrophoresis. The immunoregulatory cytokine tumor necrosis factor alpha (TNFa) recognizes two cell surface receptors. TNF-R1 (also known as CD120a) has an apparent molecular mass of 55/60kD and is constitutively expressed on all nucleated cells, whereas TNF R2 (also known as CD120b) with an apparent molecular mass of 75/80kD, is restricted to hematopoietic cells. TNF-R2 directs TNFa mediated activation and proliferation of T lymphocytes. An autocrine role for TNF and TNF-R2 is implicated in hematopoietic malignancies, and the TNF-R2 locus is a translocation target in several leukemias, suggesting a role for TNF-R2 in the development of certain leukemias. The p55 receptor extracellular domain was produced in insect cells (Sf9) infected with recombinant viruses. Source: Sf9 Biological Activity: Binding of the ligand TNF was demonstrated by receptor binding competition of binding with radioactive TNF. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNF Receptor, Extracellular Domain p55, Recombinant, Human (TNFR 1, CD120a, MGC19588, p55, p55 R, TNFR55, Tumor Necrosis Factor alpha Receptor, Tumor Necrosis Factor Binding Protein 1, TBP1, Tumor Necrosis Factor Receptor Superfamily Member 1A, TNFRSF1a) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | T9161-06N |
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| Order / More Info | TNF Receptor, Extracellular Domain p55, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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