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| Product Name | TNF, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides. Stimulated peripheral neutrophilic granulocytes but also unstimulated cells and also a number of transformed cell lines, astrocytes, microglial cells, smooth muscle cells, and fibroblasts also secrete TNF. Human milk also contains this factor. Cells expressing CD4 secrete TNF-alpha while CD8(+) cells secrete little or no TNF-alpha. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL-2, GM-CSF, SP, Bradykinin, immune complexes, inhibitors of cyclooxygenase, and PAF (platelet activating factor). Recombinant Human TNF expressed in human 293 cells has been shown to be predominantly a non-covalently linked homotrimer, with a molecular mass of 51kD. Source: Recombinant protein corresponding to human TNF expressed in HEK293. Molecular Weight: ~17kD Biological Activity: The EC50 as determined |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNF, Recombinant, Human (TNFA, Tumor Necrosis Factor, Cachectin, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a) |
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| Gene, Accession, CAS # | SwissProt: P01375 |
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| Catalog # | 500503 |
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| Order / More Info | TNF, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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