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| Product Name | TNF, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides although cells expressing CD8(+) secrete little or no TNF-alpha. In addition, TNF is secreted by peripheral neutrophilic granulocytes and by a number of transformed cell lines that include those of astrocytes, microglial cells, smooth muscle cells and fibroblasts. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL2, GM-CSF, SP, Bradykinin, Immune complexes, inhibitors of cyclooxygenase and platelet activating factor. TNF-alpha shares approximately 30% homology with TNF-beta. Human TNF-alpha is a non-glycosylated protein of 17.6kD. Source: Recombinant protein corresponding to human TNF expressed in E. coli. Molecular Weight: ~17.6kD Biological Activity: The ED50 as determined by dose dependent proliferation of IL4 stimulated human megakaryocytic cel |
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| Size | 50ug, 100ug, 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNF, Recombinant, Human (TNFSF2, Cachectin, Differentiation-Inducing Factor (DIF), Necrosin, Cytotoxin, Tumor Necrosis Factor Alpha) |
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| Gene, Accession, CAS # | SwissProt: P01375 |
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| Catalog # | 500504 |
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| Order / More Info | TNF, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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