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| Product Name | TNF, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides. Cells expressing CD4 secrete TNF-alpha while CD8(+) cells secrete little or no TNF-alpha. Stimulated peripheral neutrophilic granulocytes but also unstimulated cells and also a number of transformed cell lines, astrocytes, microglial cells, smooth muscle cells, and fibroblasts also secrete TNF. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL-2, GM-CSF, SP, Bradykinin, immune complexes, inhibitors of cyclooxygenase, and PAF (platelet activating factor). Human TNF-alpha is a non-glycosylated protein of 17kD and a length of 157aa. Mouse TNF-alpha is N-glycosylated. Homology with TNF-beta is ~30%. TNF-alpha forms dimers and trimers. Source: Recombinant protein corresponding to human TNF expressed in CHO cells. Molecular Weight: ~18kD Biological Act |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNF, Recombinant, Human (Tumor Necrosis Factor, Cachectin, TNF, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-A, TNF-Alpha) |
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| Gene, Accession, CAS # | SwissProt: P01375 |
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| Catalog # | 500505 |
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| Order / More Info | TNF, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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